What biologics are available?

There are many biologics that can be used to treat IBD. It can be hard to figure out which one is right for you. While all biologics work well in treating IBD, they also have important differences.

For example, they work in different ways. Some work by blocking signals in the immune system that cause inflammation in the intestinal tract and other parts of the body. These signals are called tumor necrosis factors (TNF) and interleukins (IL). Another biologic, Entyvio®, is gut-selective and works by binding to integrins. This blocks gut-directed immune cells from moving into the intestinal tract and helps to control inflammation. See the Tables below for a summary of how the most common biologics work and what parts of the body they affect.

Biologics also vary in how they are given and have different side effects. The next few pages will teach you more about these differences.

anti-TNF – gut, skin, joints

  • Cimzia®
  • Humira®
  • Remicade®
  • Simponi®
anti-IL – gut, skin, joints

  • Stelara®
anti-integrin - gut

  • Entyvio®
  • Tysabri® - not commonly used, also works in brain